Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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4,996 – 5,010 of 60,541 results

4,996

Selleck Chemical LLC COH-29 S0283-5MG

COH29 (RNR Inhibitor COH29) is a potent inhibitor of ribonucleotide reductase (RNR) with anticancer activity COH29 (RNR Inhibitor COH29) inhibits recombinant RNR small subunit (RRM1/RRM2) activity in vitro with IC50 of 16 M

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4,997

Sigma Aldrich Fine Chemicals Biosciences Dorzolamide hydrochloride British Pharmacopoeia (BP) Reference Standard | 130693-82-2 | MFCD00884659 |

Dorzolamide hydrochloride British Pharmacopoeia (BP) Reference Standard | Mol Wt: 360.9 | 130693-82-2 | MFCD00884659 |

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4,998

Selleck Chemical LLC Halofuginone hydrobromide E2709-25MG

Halofuginone (RU-19110) hydrobromid a febrifugine derivative is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18 3 nM Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF- activity

Pricing & Availability

4,999

Selleck Chemical LLC 1-Indanone S9346-25MG

1-Indanone (Indan-1-one Alpha-Indanone) is an oxidation product of Indan a component of fuels solvents and varnishes It is part of the steroid hormone biosynthesis and arachidonic acid metabolism pathways

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5,000

Selleck Chemical LLC Chonglou Saponin VII S9156-1MG

Chonglou Saponin VII (Dioscinin Polyphyllin-VII Paris saponin-VII) a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou) inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3 / -catenin signaling pathway

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5,001

Selleck Chemical LLC RP-102124 E4622-1G

RP-102124 is a first-in-class allosteric inhibitor of multi-Rac with activity against oncogenic Rac1b RP-102124 is orally bioavailable and exhibits dose-dependent inhibition of tumor growth in xenograft models It exhibits potent inhibition of phenotypic characteristics of Rac signaling such as cell migration and cytoskeletal rearrangements

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5,002

Selleck Chemical LLC Ladarixin E4650-1G

Ladarixin(DF 2156A free base) is a small molecule orally available allosteric and non-competitive antagonist of dual CXCR1 and CXCR2 It is able to reduce the acute and chronic neutrophilic influx and can be used in research of Asthma Idiopathic Pulmonary Fibrosis Influenza-A infection and COPD cutaneous and uveal melanoma conditions

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5,003

Selleck Chemical LLC R16 E1973-1G

R16(NSC29869 Nrf2-IN-3) is an inhibitor of NRF2 (nuclear factor erythroid 2-related factor 2) that selectively binds KEAP1 mutants and restores their NRF2-inhibitory function by repairing the disrupted KEAP1/NRF2 interactions It significantly enhances the sensitivity of KEAP1-mutated tumor cells to cisplatin and gefitinib

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5,004

Selleck Chemical LLC YJ1206 E4760-100MG

YJ1206 is an orally bioavailable highly specific and potent degrader of CDK12/13 with an IC50 of 12 55 nM in VCaP cells It increases DNA damage induces apoptosis and demonstrates robust anti-tumor activity in vivo

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5,005

Selleck Chemical LLC Tafenoquine Succinate E4946-100MG

Tafenoquine Succinate(WR 238605 Succinate Etaquine Krintafel) is an 8-aminoquinoline (8AQ) anti-malarial drug that kills both the liver and blood stages of the parasite broadening its applicability for chemoprophylaxis to all species of malaria It is specifically used for the prevention of Plasmodium vivax relapse